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Hemophilia

Sex linked disorder, on X-chromosome

How Hemophilia is Inherited:

     For those who were unaware, Hemophilia is infact a hereditary disease. This means that if a family member who is related to you by blood has this disease, you  have a chance of inheriting it yourself. That's not to say that you are 100% going to get it, but your chances are higher than a person who doesn't have Hemophilia in their family genes. As mentioned before, Hemophilia is an inherited sex-linked recessive trait, found on the X-chromosome. When it comes to Hemophilia, women are carriers. If a female carrier has a baby with a male who does not have Hemophilia, they have a 1 in 4 chance of producing a boy who will have Hemophilia, and a 1 in 4 chance the boy will not be affected. If the couple has a girl, there is a 1 in 4 chance she will be a carrier, and a 1 in 4 chance that she will be completely unaffected.

     Because males have an X-chromosome and a Y-chromosome, it is easier for them to get the mutated gene that causes Hemophilia. Since females have two X-chromosomes, they can rely on their other X-chromosome if the other one has the mutation that causes Hemophilia. It is literally impossible for a male to inherit Hemophilia from their father, because they inherit their Y-chromosome from their father and their X-chromosome from their mother. If a female inherits the mutated X-chromosome which triggers Hemophilia, it is possible that she received it from either her mother or father. The reasoning for this is because she does not inherit her father's Y-chromosome, so if her father has the mutated gene, he could very well pass it on to her. Even at this, she could still rely on her other X-chromosome, which is why Hemophilia is much more common in males than females.  

To learn more about how Hemophilia is inherited, Click here!

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